Description. Cremophor A 6 is a whitish waxy substance. Cremophor A 25 is supplied in the form of free-flowing, non-dusting microbeads. Identity. Cremophor A. August Supersedes issue dated May MEMC e/Page 1 of 8. Cremophor® A Grades. ® = Registered trademark of BASF Aktiengesellschaft. INCI: Ceteareth-6 (and) Stearyl AlcoholThe Cremophor A grades are Combinations of Cremophor A6 and Cremophor A25 can emulsify oils with a.

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Pain on injection of propofol. Such efforts increasingly involve the use of more exogenous substances and novel compounds of which thorough study must be done to ensure the greatest safety to the patient. However, freeze—thawing and extensive shaking caused droplet enlargement.

There was a decrease in cholesterol and high-density lipoprotein, however. J Oral Maxillofac Surg ; The drawbacks and advantages of vehicle selection for drug formulation.

Cremophor A6

Intensive Care Med ; 26 suppl 4: A case report and review of literature. After droplets coalesce and increase in size, they cannot be reduced in size except by rehomogenization. The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers. Crit Care Med ; Chemically, cyclodextrins are stable in base, but they are susceptible to hydrolysis in acid.


Implications on the pathogenesis of infections. Kay B, Rolly G: Are you a distributor who is interested in being listed here? The targeting of drugs parenterally by use of microspheres.

Cremophor® A 6 by BASF – Personal Care & Cosmetics

We have emailed you at with instructions on how to set up a new password. Ultimately, it is a complex interplay of intermolecular forces van der Waalsincluding thermodynamic hydrogen bonds and solvent hydrophobic interactions that allow stable inclusion complexes to be formed.

The negative electrostatic repulsive forces are derived q6 small quantities of free fatty acids and phosphatidic acids in egg yolk lecithin. Global Regulatory Lists Reviewed. Tween and Mulgofens generally produced histamine release in dogs and pigs and were not pursued.

The pharmacokinetics and pharmacodynamics of propofol in a modified cyclodextrin formulation Captisol versus propofol in a lipid formulation Diprivan: This is characterized by metabolic acidosis, multiorgan failure, lipemia, hepatomegaly, rhabdomyolysis, and death.


Z6 of albumin-stabilized propofol formulations containing low and no oil abstract. Show us the proof. Propofol emulsion administration resulted in a smaller propofol volume of distribution and shorter times to peak electroencephalographic activity at onset, loss of righting reflex, and maximal electroencephalographic effects as compared with propofol administered in the lipid-free vehicle.

A comparison with propofol-LCT. Involvement of the cervical sympathetic nervous system in the changes of calcium homeostasis during turpentine oil-induced stress in rats.


Baker, Mohamed Naguib; Propofol: Sulfite blood concentrations after sulfite propofol administration have not been reported, nor has the occurrence of allergic responses been clarified. Historical review of FDA issues surrounding sulfite allergies.

However, aseptic precautions should be maintained during propofol emulsion administration. Cyclodextrin drug carrier systems. Furthermore, emulsions need to have a great enough physical stability to withstand heat sterilization and maintain their integrity for their prescribed shelf life. Immune-mediated reactions to althesin alphaxalone.

The mechanism for propofol-induced pancreatitis is largely unknown, but hypertriglyceridemia and defects in lipid metabolism have been proposed.

Disperse Systems, vol 1. High incidences of anaphylaxis with the Cremophor EL formulation prompted its withdrawal from development. We develop new molecules for use in innovative products and solutions to improve health. Login Log in to access full content You must be logged in to access this feature. Determination of polyoxyethyleneglycerol triricinoleate 35 Cremophor EL in plasma by pre-column derivatization and reversed-phase high-performance liquid chromatography.

The information presented here was acquired by UL from the producer of the crenophor or material or original information provider.