Learn more about Cissus Quadrangularis uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Cissus. Cissus quadrangularis is an ancient medicinal plant native to the hotter parts of radical scavenging activity [5], anti-osteoporosis activity and bone healing. Cissus quadrangularis L. (veld grape) is a climber plant of Vitaceae family. A case Keywords: Cissus quandranglis; Bone healing; Fracture;.

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Although CQ by itself did not increase bone mass we observed that it decreased bone loss in the distal femoral metaphysis and proximal tibial metaphysis regions of the long bones that have both cancellous and cortical bones. It can be cultivated in plains coastal areas, jungles and wastelands up to m elevation. If CQ reduces the adipocytes in the bone marrow then boen bone resorbing properties of leptin will be reduced as local leptin concentrations produced by increased adipocytes in the bone marrow will increase bone loss [ 37 ].

However, this is the first report to show the effects of CQ on bone using densitometric morphometric analyses including actual BMD and BMC values for the different bone sites. Conflicts of interest There are no conflicts of interest.

The plant extract also facilitated extracellular matrix mineralization, which was more pronounced in the presence of osteogenic media. At the time of sacrifice, body weight was recorded.

Osteogenic potential of cissus qudrangularis assessed with osteopontin expression

Financial support and sponsorship Nil. The ability for absorption and utilization of calcium should be increased for the hastening of healing. These effects may be related to either the estrogenic properties of cissus quadrangularis as estrogen itself can increase IGF secretion from osteoblasts [27] but this has not yet been confirmed. Grouping and posology The quaadrangularis were divided into two groups, a test group and a control group.


Our thorough screening of literature available on Cissus quadrangularis depicted an interesting fact that though the plant is a popular remedy quadrangularie a variety of ailments and a range of formulations has been marketed, little effort have been made to verify its purity, quality quadrrangularis efficacy through scientific screening. Rapid the utilization of these raw ciszus earlier will be completion of healing process.

Pain, swelling, fragment mobility, serum calcium, and serum phosphorus were recorded pre- and post-operative. Udupa KN, Prasad G. More evidence is required, as the one study noting that cissus was ineffective in isolation noted that combination therapy with cissus and calcium was quite effective.

An increase in creatinine has been noted alongside weight loss; practical significance of this information is not known.

The cortical cells are filled with cisuss contents. Strength as per Ayurvedic Pharmacopoeia of India: Scanning Electron Microscopy ; 1: It has greater impact on osteoblastic proliferation than other cellular responses.

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The cause of trauma, interval from injury to trial of drug, average age, gender, and site distribution were all reviewed and recorded on a set proforma. Quadrangulais, CQ has been linked to several health benefits such as antiobesity [ 6 ], reduction of proinflammatory cytokines [ 7 ], anti-inflammatory [ 8 ], antioxidant [ 9 ], antiglucocorticoid [ 10 ], and antidiabetic properties [ 11 ].

Paste of alcoholic extract of the plant was locally as well as intramuscularly facilitates rapid healing of fracture in albino rats. This may be justified as OPN is multifunctional during fracture healing and has role in various phases of fracture healing.

Supplementing for better joint health A: Lipid constituents of Cissus quadrangularisPhytochemistry ; Needless to mention that the root and stem extracts of the plant CQ have therapeutic efficacy and are known to possess antioxidant, antimicrobial activity, and cisssus routinely used to accelerate the process of bone fracture healing.

Osteogenic potential of cissus qudrangularis assessed with osteopontin expression

Its traditional usages are mostly catered around treating feminine disorders menopause, libido, and menstrual disorders or treating bones increasing bone mass or accelerating quaerangularis healing rates which gives it the traditional name of the ‘Bone Setter’; some other traditional usages are in regards to its supposed antiulcer properties, antihemhorroid properties, and pain relieving properties.


Biomechanical and Calcium studies on vissus effect of Cissus quadrangularis in fracture repair. Data of second and third sampling were compared with data of first sampling and expressed in relative quantities fold change.

Pharmacological and therapeutic activity of Cissus quadrangularis: Article Information Sr No: Plant material occurs as pieces of varying lengths; stem quadrangular, 4-winged, internodes cm long and cm thick The surface is smooth, glabrous, buff colored with greenish tinge, angular portion reddish-brown; no taste and odour.

Osteopontin is an extracellular matrix protein with ccissus localization and functionality that has multiple, stage-dependent roles during fracture healing.

Pharmacognostic and traditional properties of Cissus quadrangularis Linn — Bne overview. Immediate postoperative for 3 days same drugs such as antibiotics combination of injection amoxicillin, with clavulanic acid combination mg intravenous [IV] and analgesics injection Dynapar AQ 75 mg IV were given.

Hospital ethical committee approved the study ref no.

In future study, the isolated principles from Cissus quadrangularis needs to be evaluated in scientific manner using specific experimental animal models and clinical trials to understand the molecular mechanism of action, in search of lead molecule from natural resources.

We observed that there were no statistical differences between the levels, of either of these markers in any of the groups studied; therefore, CQ does not alter the levels of these markers.