Merkel-cell carcinoma (MCC) is a rare and highly aggressive skin cancer, which, in most cases, is caused by the Merkel cell polyomavirus (MCPyV or MCV). Merkel cell carcinoma, also called neuroendocrine carcinoma of the skin or trabecular cancer, is a very rare type of skin cancer that forms when. Los hallazgos clínicos más característicos son el rápido crecimiento y la ausencia de dolor. Aunque el carcinoma de células de Merkel puede afectar cualquier.
|Published (Last):||20 July 2014|
|PDF File Size:||4.20 Mb|
|ePub File Size:||16.79 Mb|
|Price:||Free* [*Free Regsitration Required]|
Case report and literature review. The etiological factors include, above all, sun exposure, as demonstrated by the fact that most lesions occur in exposed areas, especially the periorbital region. National Comprehensive Cancer Network guidelines recommend PD-1 inhibitorseither nivolumabpembrolizumab or avelumab, for patients with disseminated MCC;systemic therapy is not recommended for early stage MCC.
It is similar to small cell lung carcinoma, with an intrinsic sensitivity to chemo-radiotherapy and a remarkable tendency to metastasize. Case description A 72 year-old woman was seen in our clinic for a rapidly growing, nodular, erythematous skin lesion with a shiny surface Figs.
Travesera de Gracia,Barcelona, Barcelona, ES, maxilo elsevier. The response to chemotherapy generally is of short duration and patients ultimately die from the disease. Several factors are involved in the pathophysiology of MCC, including a virus called Merkel cell polyomavirus MCVultraviolet radiation UV exposure, carcinooma weakened immune function.
Infectious diseases — viral systemic diseases A80—B34— In viral status, MCV large tumor antigen LT antigen and retinoblastoma protein RB protein expression correlates with more favorable prognosis, while p63 expression correlates with a poorer prognosis. Cells in nearly any part of the body can become cancer, and can then spread to other parts of the body.
Carcinoma cutáneo de células de Merkel: Presentación de un caso y revisión de la literatura
There was a significant benefit of adjuvant nodal therapy, megkel only when the SLNB was positive. In consequence, if metastasis is diagnosed, treatment is merely palliative. No specific staging system for Merkel cell carcinoma exists, 7 but the tumor is generally classified as: Merkel cells; Merkel cancer; Skin cancer. The existence of disseminated disease reduces mean survival to less than 9 months.
Regular self-examination of the skin should be done every month and a check once a year with a qualified dermatologist. merkell
[Merkel cell carcinoma experience in a reference medical center.]
Merkel cell carcinoma is an infrequent variety of skin cancers of neuroendocrine origin, which traditionally is described as the skin malignancy with the worst prognosis. The Journal of Pathology. Journal of the National Cancer Institute. These cancers most often start on skin that’s exposed to the sun, like the face the most common siteneck, and arms. The purpose of Wikipedia is to present facts, not to train.
It has been shown to be effective in reducing the rates of recurrence and in increasing the survival of patients with MCC. For example, following are some general rules for skin protection: Inthe annual incidence celulss was around 0. Cutaneous Merkel cell carcinoma.
Lymph node involvement frequently appears as large lymph node clumps that may be inoperable. Treatment The primary objective of treatment must be the local and regional control of the primary lesion and associated lymph nodes, which improves the quality of life and reduces the risk of disease dissemination. Cancer starts when cells begin to grow out of control.
Regression of the main lesion has been documented. Views Read Edit View history. This skin cancer occurs most often in Caucasians between 60 and 80 years of age, and its rate of incidence is about twice as high in males as in females. Annals of Surgical Oncology.
It is important to study the extension of the disease when the diagnosis is made. Complete excision is associated with significant higher survival rates.
El Carcinoma de Células de Merkel
The lesion was excised under general anesthesia with oncological margins and the skin was merkek with a cervicofacial rotation-sliding skin flap Fig. Our patient underwent surgery followed by radiation therapy approximately one month after the intervention. In our patient, because of the absence of skeletal involvement, a broad excision was made with 3-cm margins except for the edge of the eyelid, where the margin was 2 cmincluding underlying periostium to rule out the presence of bone involvement.
Tang C, Toker C.
Apply sunscreen 30 minutes before outdoor activity and reapply every 2 hours. The existence of satellite lesions and cutaneous spread should be investigated and lymphatic drainage chains should be palpated.
MCV is a common human infection that can be detected by conformational capsid epitope immunoassays”. Merkel cells are thought to be a type of skin neuroendocrine cellbecause they share some features with nerve cells and hormone-making cells.