PDF | The present study aims to evaluate the therapeutic properties of the medicinal plants (Vitex negundo, Aegle marmelos and Boswellia serrata) for their . Abstract To evaluate the anti-inflammatory activity of Vitex negundo (VN) leaf extract and its mechanism of action in experimental animals. Carrageenin induced. Abstract. The present study was undertaken to assess the anti-inflammatory effect of ethanolic extract of Vitex negundo roots in rats.

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The pink colour complex of thiobarbituric acid reacting substances was monitored at nm 8 — Anti-inflammatory effect of Vitex negundo extract in albino rats By carrageenin induced rat hind paw edema method. Albino rates of either sex weighing gm were procured from Animal House of Kota Jegundo of Pharmacy, Kota, Rajasthan, and were selected in the study.

More over anti-ulcer activity of VN reported by Sahni et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Necessary permission was obtained from the Institutional Animal Ethics Committee.

Author information Article notes Copyright and License information Disclaimer. State of the art.

Studies on analgesic and anti inflammatory activity of Vitex negundo Linn. For mechanism of action: The animals were divided into five groups with each group consisting of ten animals.


The present work was undertaken to evaluate the antioxidant potential and anti-inflammatory activity of the plant.

Studies on analgesic and anti-inflammatory activities of Vitex negundo Linn. Free Radical scavenging activity of Syzygium cumuni and Ficus bengalensis plants used in Ayurveda for Diaibetus mellitus.

Antioxidant and Antiinflammatory Activity of Vitex negundo

J of Med and Aromat Plant Sci Please leave infammatory message, we will get back you shortly. Ethanolic leaf extract of VN in the form of suspension was fed orally in a volume of 10 mL kg -1 wt. It was identified and authenticated by an expert botanist from J.

Ayurveda mentions several plants acting as antiinflammatory agents in arthritic disorders. Curcumin was used as positive control. Gandevi GujaratIndia, Tel: Guidelines Upcoming Special Issues. Preliminary studies on antiinflammatory activity of Zingcher officinal Rosc. J Agri Food Chem The difference in wet and dry weights of granuloma from control group to that of treated group indicates the anti-inflammatory activity.

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Non-steroidal anti-inflammatory drugs; p. It belongs to the family Rutaceae [ 2 ]. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Natural phenolic in the prevention of UV-induced skin damage: The filtrates were kept on water bath to obtain the crude extract [ 10 ].

Screening of anti-inflammatory activity of certain indigenous drugs on carrageenin induced activlty paw oedema in rats. Pharmacological Experiment on Isolated Preparations.

Antioxidant and Antiinflammatory Activity of Vitex negundo.

The maximum anti-inflammatory action was observed in 3 h in all the doses of test drug. Carrageenin induced edema in hind paw of negyndo as assay for anti-inflammatory drugs. Effects of anhi drugs on oxytocin induced rat uterus contractions were compared to original response of oxytocin in term of height in cms, which served as control.


Statistical analysis was carried out by applying student’s t-test. Kundnani College of Pharmacy. Leaves are applied externally to bruises and eruption [ 9 ].

X 7 days p. Five groups of 6 mice each were administered with aqueous extract at 1. Mice were fasted overnight before the day of experiment and the liver was promptly excised after sacrificing the mice. Inhibitory effect of Vitex-negundo extract on oxytocin induced contractions in rat uterus in a dose dependant manner. The parameter observed and recorded was changed in behavioral, neurologic and autonomic responses. The carrageenan-induced paw edema in rats is believed to be biphasic. Carrageenin induced hind paw edema and cotton pellet granuloma test in albino rats were employed to study the anti-inflammatory activity of Vitex negundo VN leaf extract.

Antioxidant and antiinflammatory activity of Vitex negundo.

Group I of cotton granulona test receiving distilled water served as diseased control. The results were compared with Group I. The difference between 1 h and subsequent hours reading was taken as actual edema volume [ 12 ].