Inhibition of enzymes involved in adenosine degradation potentiated the acupuncture-elicited increase in adenosine, as well as its anti-nociceptive effect. This impressive paper is the first set of studies to identify a critical role for adenosine in the local mechanism of manual acupuncture in inflammatory and. Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture. Nanna Goldman1, 4, Michael Chen1, 4, Takumi Fujita1, 4, Qiwu Xu1, Weiguo.

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Another overhyped acupuncture study misinterpreted David Gorski on June 2, Accordingly you may only post Material that you have the right to do so. Register Already registered with FPrime?

FPrime is an expert-curated resource to help you find the articles of greatest interest and relevance to you. This sensitivity peaked at day four or five and then decreased. Acupuncture is typically kediate to deep tissue, including muscle and connective tissue, and acupoints may better overlap with their proximity to ascending nerve tracks than to the density of cutaneous afferents.

One may speculate that other non-allopathic treatments of chronic pain, such as chiropractic manipulations and massage, modalities that involve the mechanical manipulation of joints and muscles, might also be associated with an efflux of cytosolic ATP that is sufficient to elevate extracellular adenosine. Recommendations Abstract Comments You have reached your article limit.

Although it is located on the leg, just inferior and lateral to the knee, the Zusanli acupuncure is described among traditional Chinese medicine TCM practitioners as the leg portion of the stomach meridian.

You are an Editor for the journal in which the article is published.

Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture – Semantic Scholar

I could equally point out that the IRS allows medical deductions for the services of Christian Science prayer healers. Provide sufficient details of any financial or non-financial competing interests to enable users to assess whether your comments might lead a reasonable person to question your impartiality. Instead of working to anti-nocicephive these observations into usable therapies, now Nedergaard and her collaborators will likely use their preliminary data to apply to NCCAM for a grant to study adenosine in acupuncture further, rather than pursuing this observation in a manner far more likely to lead to a clinical benefit in human beings.


No, it does not. Absent evidence from the current study showing that stimulating the skin results in the release of adenosine and subsequent blunting of the pain response in the extremities of these mice, Nedergaard would have been better off leaving this entire paragraph out of the paper.

In contrast, rffects involves actually sticking needles into the skin.

Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture

Finally, there are two remaining huge problems with this paper. Adenosine A1 Receptor adenosine metabolic process. The Guardianfor instance, states:.

Where the hell were the reviewers?

Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture.

anti-nociiceptive But add the acupuncture to it, and you sex it up and get a paper into a high impact journal, which is apparently what happened here. I am an author of this article. Purinergic signalling in the nervous system: So what does this all mean? The only thing in common with acupuncture in this study is the needle sticking part, and the investigators might as well conclude that this ant-nociceptive validates ear piercing for pain relief.

So much the pity. This Agreement shall begin on the date hereof.

Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture.

Register for day free trial Anti-noociceptive is free and only takes a moment, or anti-nociceptivs for unlimited access. Even better, this effect was not observed in mice genetically engineered not to make the adenosine A1 receptor, known as A1 receptor knockout mice, strong evidence that it was the A1 receptor that was responsible for the observed blunting of the pain response.


Why do male mice spit soluble enzymes that hydrolyze extracellular nucleotides? The discovery challenges a widely held view among scientists that any benefit patients feel after having acupuncture is purely due to anti-nocixeptive placebo effect. Posted by David Gorski Dr. New Finding Interesting Hypothesis. These terms shall be governed locql and construed in accordance with English Law.

Thus, according to acupuncturists, most associated with stomach and abdominal problems far more than lower extremity pain. These guys have found something that may even have a potential clinical application. Recommend FPrime to your librarian or information manager to request an extended free trial for all users at your institution. By posting or uploading Material you warrant and represent that: First of all, this study is actually interesting for its implications for adenosine as a mediator of both inflammatory and neuropathic pain.

Apparently in the mouse adenosine has a lot to do with modulating pain adenoaine in peripheral nerves, and apparently a fair number of pharmaceutical companies are interested in developing adenosine agonists to take advantage of this effect in humans.

As in acupuncture, adenosine may accumulate during these treatments and dampen pain in part by the activation of A1 receptors on sensory afferents of ascending nerve tracks. Unfortunately, that money is largely wasted. Pentostatin treatment combinations in chronic lymphocytic leukemia. Consider anti-nociceptivd following examples, but note that this is not an exhaustive list: